Antifungal polymeric nanocapsules of polycaprolactone (PCL) and geranyl cinnamate

Referencia Apresentador Autores
Ana Carolina Vivan Zanetti, M.(Universidade Federal de Santa Catarina); Vivan, A.C.(Universidade Comunitária da Região de Chapecó); Oliveira, D.d.(Universidade Federal de Santa Catrina); Araújo, P.H.(Universidade Federal de Santa Catarina); Fiori, M.A.(Universidade Comunitária Regional de Chapecó); Fagundes, P.(Universidade Comunitária da Região de Chapecó); Carniel, T.K.(Universidade Comunitária da Região de Chapecó); Dalcanton, F.(Universidade Comunitária da Região de Chapecó); Silva, L.L.(Universidade Comunitária da Região de Chapecó); The issue of health and food safety has led industries to replace synthetic preservatives with natural additives, especially from plants. Natural extracts and essential oils have been studied for a long time due to their antimicrobial properties and could be used widely in industrial sector, especially in food area. Geraniol is natural oil that has excellent antibacterial properties but prone to degradation in the presence of oxygen, light, heat, moisture and other aggressive agents, making them unstable, which makes their conservation. In addition, the application of the essential oils in active packaging involves difficult operations because natural oils are very sensitive to thermal effects during the manufacture processes. One way to mitigate the negative effects of thermal and chemical decomposition is to encapsulate the essential oils in more resistant structures. Polycaprolactone (PCL) is a compound that has been used for this purpose to encapsulate many organic compounds. PCL is a semicrystalline aliphatic polyester, considered a biocompatible material with high permeability to essential oils. This polymer also has a low glass transition temperature of -60°C, a melting point of 60°C, and exhibits high temperature decomposition around 350°C. Its wide application is due to the fact that PCL is approved by FDA for biomedical and food applications. PCL is highly feasible for the processing of conventional thermoplastic material, added to its high solubility in a large number of organic solvents, it allows to obtain different types of devices, such as nano or microcapsules with potential application as antifungal additives in paper and in active packaging. geranyl cinamate, a derivative of the esterification reaction between geraniol and cinnamic acid, although not well known in the literature, presents indications of antimicrobial and antioxidant properties. One possible alternative to the use of geranyl cinnamate in high-temperature processes is the encapsulation of these molecules in a structure that is not toxic and is resistant to thermal treatment. This work investigated the encapsulation process by miniemulsion with evaporation of the solvent of geranyl cinnamate in PCL and the antifungal properties of nanocapsules against Penicillium variabile and Aspergillus niger. Different concentrations of geranyl cinnamate capsules were diluted in 20 mL of Sabouraud Dextrose Agar with Chloramphenicol and placed in disposable Petri dishes. The fungi were then picked up on the plates which were then placed in an oven for seven days at the average temperature of 35°C. The results obtained show that the geranyl cinnamate capsules inhibited the growth of the fungi Penicillium variabile and Aspergillus niger up to the concentration of 1.25 mg of capsules.mL-1, thus proving the effectiveness of the capsules against the fungi tested. The results suggested that these capsules have great potential for future applications in the food packaging for example.
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